Product Introduction

The vial liquid filling line is composed of ultrasonic vial washing machine, dryer sterilizer, vial injectable filling machine, vial stoppering machine and vial capping machine. It can complete spraying water, ultrasonic cleaning, flushing of inner and outer wall of bottle, preheating, drying and sterilization, heat source removing, cooling, bottle unscrambling, (nitrogen pre-filling), filling, (nitrogen post-filling), stopper unscrambling, stopper pressing, cap unscrambling, capping and other complex functions, realizing automatic production of the whole process. Each machine can be used separately, or in linkage line. The whole line is mainly used for filling of vial liquid injections and freeze-dried powder injections in pharmaceutical factories, it can also be applied to production of antibiotics, bio-pharmaceuticals, chemical pharmaceuticals, blood products etc.

Application range:

The Vial Filling Production Line is suitable for the production of 2-25ml vial liquid injections. It can complete twenty or so processes, including spraying water, ultrasonic rough washing, water flushing of bottle outer wall, two times recycled water flushing of bottle inner wall, air blowing, clean water flushing, two times clean air blowing, blowing of bottle outer wall, preheating, drying, sterilizing and pyrogen removing, cooling, nitrogen pre-filling, filling, nitrogen post-filling, stoppering, capping and so on.

Our advantages

Vial bottle washing machine

1. This Vial Filling Production Line is composed of vertical ultrasonic bottle washing machine, hot air circulating sterilizing tunnel oven and vial filling and stoppering machine, capping machine and each machine can also be used separately.

2. The ultrasonic bottle washing machine adopts a mechanical arm to clamp bottles and therefore is suitable for vial bottles with various specifications;

3. The ultrasonic bottle washing machine has good cleaning effect and saves energy by reciprocated tracking and inserting spraying needle into the bottle for water and air washing, and it is equipped with an anti-vibration rack;

4. The ultrasonic bottle washing machine separates its water spraying process from all water pipelines, thus avoiding cross contamination and complying with the GMP requirements;

5. The ultrasonic bottle washing machine is added with a bumper block for the bottle feeding screw to protect it and reduce bottle breaking risks;

6. The ultrasonic bottle washing machine adopts imported synchronous belt to connect to the block used for transferring the washed vials, with stable and reliable operation;

Vial bottle drying and sterilizing tunnel oven

1. Heated by hot circulating air, the hot air circulating sterilizing tunnel oven is energy-efficient with uniform temperature inside;

2. The hot air circulating sterilizing tunnel oven has protection function against sudden power failure, thus keeping safe operation;

3. The hot air circulating sterilizing tunnel oven is equipped with circulating water cooling device, which doesn’t consume air volume in the room, reduces the risk of pressure difference imbalance and has satisfactory cooling effect;

4. The hot air circulating sterilizing tunnel oven is configured with automatic pressure difference balance adjustment system to minimize high temperature discrepancy and temperature rise in the filling room and washing drying room, etc., caused by pressure difference imbalance between the room and the oven.

5. The hot air circulating sterilizing tunnel oven is configured with DOP test port for testing air pressure, air speed and dust particles;

6. The hot air circulating sterilizing tunnel oven has sterilization function at the cooling section (specially required for FDA);

Vial filling stoppering capping machine

1. The filling machine transfers bottles with horizontal synchronous belt at a high speed. It has accurate operation and facilitates change parts replacement;

2. A certain distance between the conveyor (on which bottles are transferred) and the work surface is reserved, which is conducive to the passage of class 100 laminar flow and the prevention of pollution to the medicine liquid resulted from turbulent flow;

3. The stoppering part of the filling machine offers stoppers in horizontal direction with a horizontal disc, which is convenient for observation, filling and high-speed stopper delivery;

4. The filling machine can be equipped with ceramic pump, stainless steel pump and peristaltic pump;

5. The filling machine has no bottle no filling and no bottle no stoppering functions;

6. Optional filling servo system can be adopted in the filling machine (eg. Delta, Mitsubishi, Schneider).

7. PLC (programmable logic controller) master control, frequency converter and touch screen control technology are adopted with stable and reliable operation; the touch screen can display the running status of each single machine, water pressure, air pressure, wind pressure, temperature, etc. of each control point, the on-off state of each switch and fault, self-diagnosis and fault analysis and troubleshooting methods, enabling the entire production process to achieve automatic control. The three-machine automatic balancing device is used in the production line to guarantee balanced and reliable production.

Optional Function

The following configurations can be adopted according to the customers’ requirements:

1. Control systems of such brands as Siemens, Schneider, Mitsubishi and Delta;

2. On-line detection of water and air pressure, water temperature and ultrasonic intensity, dust particles and wind speed, alarm and record function and printing system;

3. ORABS, CRABS and sterile isolator system.